The Indianapolis Colts are facing a daunting challenge in Week 5 as they prepare for their divisional matchup against the Jacksonville Jaguars.

In a significant setback, the Colts have ruled out several key starters for the game, which could impact their ability to remain competitive in the AFC South.

Injuries Pile Up for the Colts

Indianapolis announced on Friday that multiple critical players will not be available for Sunday’s game. Among the key absentees are **running back Jonathan Taylor, defensive tackle DeForest Buckner, and cornerback Shaquille Leonard—all of whom have been essential contributors for the Colts in recent seasons.

Taylor, who is returning from an ankle injury that has kept him out for much of the season, was initially expected to be a game-time decision.

However, the team confirmed he would not play, leaving Indianapolis without their primary offensive weapon. Taylor’s absence will put added pressure on the Colts’ backfield, which is already struggling with consistency.

Backup running back Zack Moss will likely see the bulk of the carries, though the lack of a healthy Taylor could further limit the Colts’ offensive options against Jacksonville’s stout defense.

Defensively, the absence of Buckner—a force in the middle of the Colts’ defensive line—creates another gap that Jacksonville’s high-powered offense can exploit. Buckner has been a consistent playmaker, both as a run-stopper and a pass rusher.

Without him, the Colts will need to rely on lesser-known players to step up and contain Jacksonville’s running game, led by Travis Etienne, and its quick-hitting passing attack orchestrated by quarterback Trevor Lawrence.

Perhaps the most impactful absence is that of Leonard, a Pro Bowl linebacker who has been battling a lingering back issue. Leonard has been a pivotal part of the Colts’ defensive scheme, known for his playmaking ability and leadership on the field. His loss will be keenly felt, particularly as the Colts face a Jacksonville offense that can attack from all angles.

Colts’ Uphill Battle Against the Jaguars

The Colts are already struggling to find consistency on both sides of the ball this season, and the absence of these critical starters only compounds their issues.

Quarterback Anthony Richardson, in just his rookie season, has shown promise but is still learning the ropes. Facing a Jacksonville defense that boasts speed and discipline will only make his task more difficult.

The Jaguars, on the other hand, enter the game as the favorites and will look to capitalize on the Colts’ depleted lineup. Jacksonville is coming off a dominant performance in Week 4 and will look to build momentum with a win in front of their home crowd.

While the Colts will be shorthanded, they’ll need to dig deep if they hope to pull off an upset. The Jaguars’ defensive and offensive units are firing on all cylinders, making Sunday’s matchup a tough hill to climb for Indianapolis.